corpus.blog
41554 blogs · [ { "id": "01a087c5-cf03-702b-bcb3-87120da4d1b4", "title": "Reclaiming the missing positive", "url": "https://plengegen.com/blog/missing-positive/", "published_at": "2026-06-30T21:33:31+00:00" }, { "id": "01a087c5-cf04-7164-9cbe-8ba42b5e94b4", "title": "The Jagged Line: Why the Best Careers Never Run Straight", "url": "https://plengegen.com/blog/jagged-line/", "published_at": "2026-06-26T17:44:46+00:00" }, { "id": "01a087c5-cf04-7164-9cbe-8ba42bcc17df", "title": "Connected by Design: How AI and Automation are Transforming Drug Discovery at BMS", "url": "https://plengegen.com/blog/rube-goldberg/", "published_at": "2026-05-05T14:40:01+00:00" }, { "id": "01a087c5-cf04-7164-9cbe-8ba42cc6dd6f", "title": "Breaking from the Herd: How Biopharma Can Escape Moloch’s Trap", "url": "https://plengegen.com/blog/moloch/", "published_at": "2026-04-10T19:00:02+00:00" }, { "id": "01a087c5-cf04-7164-9cbe-8ba42d831295", "title": "The race between the bull and the bear: U.S. biopharma outlook in 2026", "url": "https://plengegen.com/blog/outlook-2026/", "published_at": "2026-01-29T00:31:56+00:00" }, { "id": "01a087c5-cf04-7164-9cbe-8ba42dbacde3", "title": "From Sapling to Forest: Blended Innovation and the Future of Drug Discovery", "url": "https://plengegen.com/blog/blended/", "published_at": "2026-01-08T02:09:57+00:00" }, { "id": "01a087c5-cf04-7164-9cbe-8ba42dcf424b", "title": "Smart Bets, Bold Science: Building Winning Hands in Drug Discovery", "url": "https://plengegen.com/blog/v2f/", "published_at": "2025-10-27T18:01:23+00:00" }, { "id": "01a087c5-cf04-7164-9cbe-8ba42ec0c011", "title": "Optimizing value creation in biopharma is like “the flop” in Texas hold ‘em", "url": "https://plengegen.com/blog/cvcp/", "published_at": "2025-03-27T16:57:52+00:00" }, { "id": "01a087c5-cf04-7164-9cbe-8ba42f3e4372", "title": "AI Unleashed: Transforming Drug Discovery from Theory to Practice", "url": "https://plengegen.com/blog/ai-sequel/", "published_at": "2025-01-07T20:07:01+00:00" }, { "id": "01a087c5-cf04-7164-9cbe-8ba42fab1114", "title": "Advice to my younger self", "url": "https://plengegen.com/blog/advice-younger-self/", "published_at": "2024-09-27T17:19:01+00:00" }, { "id": "01a0bdcf-a56e-7362-bb08-865f43930b39", "title": "Sequential immunotherapy for functional cures in autoimmunity", "url": "https://plengegen.com/blog/seqimm/", "published_at": "2024-06-05T12:10:24+00:00" }, { "id": "01a0bdcf-a56e-7362-bb08-865f44148381", "title": "Increasing R&D productivity: “Bullseye, Aim, Fire!”", "url": "https://plengegen.com/blog/bullseye-aim-fire/", "published_at": "2023-09-27T19:26:16+00:00" }, { "id": "01a0bdcf-a56e-7362-bb08-865f4494e189", "title": "Discovery moments: TYK2 pseudokinase inhibitor", "url": "https://plengegen.com/blog/tyk2/", "published_at": "2023-01-28T13:24:11+00:00" }, { "id": "01a0bdcf-a56e-7362-bb08-865f457346cb", "title": "The AI Challenge in drug discovery and development: What is “truth”? ", "url": "https://plengegen.com/blog/ai-truth/", "published_at": "2022-01-07T00:45:19+00:00" }, { "id": "01a0bdcf-a56e-7362-bb08-865f4607f2d9", "title": "Is drug R&D more like poker or chess?", "url": "https://plengegen.com/blog/poker-vs-chess/", "published_at": "2021-11-15T18:24:17+00:00" }, { "id": "01a0bdcf-a56e-7362-bb08-865f46cdc7d3", "title": "Programmable therapeutics – more than pure imagination", "url": "https://plengegen.com/blog/pgtx-imagination/", "published_at": "2021-05-28T20:28:45+00:00" }, { "id": "01a0bdcf-a56e-7362-bb08-865f46dbd071", "title": "Guest blog: Lessons Learned from Misadventure – Kristen Hege", "url": "https://plengegen.com/blog/hege/", "published_at": "2021-03-10T10:46:06+00:00" }, { "id": "01a0bdcf-a56e-7362-bb08-865f471243cc", "title": "Creating a “virtual bubble” for safe return in K-12 schools", "url": "https://plengegen.com/blog/k-12_virtual-bubble/", "published_at": "2020-09-09T12:33:52+00:00" }, { "id": "01a0bdcf-a56e-7362-bb08-865f480717e6", "title": "Drug repurposing in SARS-CoV-2 / COVID-19: preventing the maladaptive immune response leading to critical disease requiring ICU care.", "url": "https://plengegen.com/blog/repurposing-covid19/", "published_at": "2020-04-08T00:31:12+00:00" }, { "id": "01a0bdcf-a56e-7362-bb08-865f488f2f7b", "title": "The clickable genome: click on any gene and generate a function-phenotype map (i.e., genetic dose-response curve)", "url": "https://plengegen.com/blog/assumptions/", "published_at": "2020-01-12T15:22:26+00:00" }, { "id": "01a0bdd3-ace6-726a-9b0e-cc59c63f5ec1", "title": "Mechanism, magnitude, and markers, oh my!", "url": "https://plengegen.com/blog/3ms/", "published_at": "2019-09-28T19:59:48+00:00" }, { "id": "01a0bdd3-ace6-726a-9b0e-cc59c6c888bf", "title": "Adverse drug event (ADE) phenome-wide association study (PheWAS) with ACLY gene", "url": "https://plengegen.com/blog/acly/", "published_at": "2019-03-26T09:57:13+00:00" }, { "id": "01a0bdd3-ace6-726a-9b0e-cc59c7905c65", "title": "Tipping point for digital health in drug discovery and development", "url": "https://plengegen.com/blog/digital-health/", "published_at": "2019-01-06T18:20:45+00:00" }, { "id": "01a0bdd3-ace6-726a-9b0e-cc59c849e7fb", "title": "How to build a genetic dose-response portal in 7 years", "url": "https://plengegen.com/blog/portal-instructions/", "published_at": "2018-12-09T13:36:13+00:00" }, { "id": "01a0bdd3-ace6-726a-9b0e-cc59c8ce13a2", "title": "Pharmacogenetics by design (not by accident)", "url": "https://plengegen.com/blog/pgx-by-design/", "published_at": "2018-10-21T11:38:28+00:00" }, { "id": "01a0bdd3-ace6-726a-9b0e-cc59c916a057", "title": "A tale of tails: polygenic risk scores and healthcare reimagined", "url": "https://plengegen.com/blog/tale-tails-polygenic/", "published_at": "2018-08-28T00:10:23+00:00" }, { "id": "01a0bdd3-ace6-726a-9b0e-cc59c9d656d0", "title": "Protein quantitative trait loci (pQTLs): an emerging resource for genetic-driven drug discovery", "url": "https://plengegen.com/blog/pqtl/", "published_at": "2018-06-07T01:10:16+00:00" }, { "id": "01a0bdd3-ace6-726a-9b0e-cc59ca0f8f61", "title": "Matching therapeutic modality and molecular mechanism", "url": "https://plengegen.com/blog/matching-modality-moa/", "published_at": "2018-05-01T09:45:55+00:00" }, { "id": "01a0bdd3-ace6-726a-9b0e-cc59cb00cec3", "title": "NASH, HSD17B13 and era of programmable therapeutics", "url": "https://plengegen.com/blog/hsd17b13/", "published_at": "2018-04-13T21:47:08+00:00" }, { "id": "01a0bdd3-ace6-726a-9b0e-cc59cbef1c40", "title": "Genetically driven tissue-specific pathogenicity", "url": "https://plengegen.com/blog/escaperoom/", "published_at": "2017-12-28T21:18:51+00:00" }, { "id": "01a0bdd7-0490-7002-803f-54e839eff412", "title": "PheWAS and FinnGen", "url": "https://plengegen.com/blog/phewas-finngen/", "published_at": "2017-12-19T10:17:24+00:00" }, { "id": "01a0bdd7-0490-7002-803f-54e83aa61e80", "title": "Celebrating new therapeutic modalities", "url": "https://plengegen.com/blog/modalities/", "published_at": "2017-09-27T15:20:52+00:00" }, { "id": "01a0bdd7-0490-7002-803f-54e83b0e737b", "title": "Omnigenic drug discovery", "url": "https://plengegen.com/blog/omnigenic/", "published_at": "2017-06-19T10:44:38+00:00" }, { "id": "01a0bdd7-0490-7002-803f-54e83bc912ee", "title": "Human genetics to predict therapeutic window: case study with BAFF and belimumab", "url": "https://plengegen.com/blog/baff/", "published_at": "2017-04-30T15:31:54+00:00" }, { "id": "01a0bdd7-0490-7002-803f-54e83cb8786f", "title": "Call for a Human Knockout Project for drug discovery & development", "url": "https://plengegen.com/blog/humanko/", "published_at": "2017-04-23T12:54:17+00:00" }, { "id": "01a0bdd7-0490-7002-803f-54e83d9ad30c", "title": "Odds & ends: this week’s examples of a discipline approach to R&D", "url": "https://plengegen.com/blog/examples/", "published_at": "2017-03-31T11:39:26+00:00" }, { "id": "01a0bdd7-0490-7002-803f-54e83dd97596", "title": "Make no mistake: PCSK9 and the FOURIER clinical outcome study represent a triumph for genetic-driven drug discovery", "url": "https://plengegen.com/blog/pcsk9-fourier/", "published_at": "2017-03-24T12:22:55+00:00" }, { "id": "01a0bdd7-0490-7002-803f-54e83e800ace", "title": "Article of the week: substrate reduction therapy for Parkinson’s disease guided by a biochemical understanding of GBA mutations", "url": "https://plengegen.com/blog/srt-gba-pd/", "published_at": "2017-03-15T21:28:02+00:00" }, { "id": "01a0bdd7-0490-7002-803f-54e83eae0f72", "title": "The inconvenient path of precision medicine in drug development", "url": "https://plengegen.com/blog/inconvenient-prec-med/", "published_at": "2017-03-09T15:41:02+00:00" }, { "id": "01a0bdd7-0490-7002-803f-54e83f6c6756", "title": "Towards programmable therapeutics", "url": "https://plengegen.com/blog/programmable-therapeutics/", "published_at": "2017-03-02T18:43:29+00:00" }, { "id": "01a0bddb-51bb-7121-ac62-336995ef4364", "title": "Polygenic models for drug discovery | ultra-rare variants in schizophrenia", "url": "https://plengegen.com/blog/urv-scz/", "published_at": "2016-10-05T10:07:16+00:00" }, { "id": "01a0bddb-51bb-7121-ac62-33699691455d", "title": "Short blog on academic-industry partnerships", "url": "https://plengegen.com/blog/ac-ind-partn/", "published_at": "2016-09-15T13:21:33+00:00" }, { "id": "01a0bddb-51bb-7121-ac62-336996a7f78c", "title": "Beware of the personal narrative: failure is inherent to success", "url": "https://plengegen.com/blog/failure/", "published_at": "2016-08-12T16:33:22+00:00" }, { "id": "01a0bddb-51bb-7121-ac62-3369970b4fad", "title": "Commentary on my STM Perspective, “Disciplined approach to drug discovery and early development”", "url": "https://plengegen.com/blog/stm-commentary/", "published_at": "2016-07-28T10:08:00+00:00" }, { "id": "01a0bddb-51bb-7121-ac62-336997bf032b", "title": "Commentary on Discussion Paper by Munos and Orloff, “Disruptive Innovation and Transformation of the Drug Discovery and Development Enterprise”", "url": "https://plengegen.com/blog/commentary_munos_nam/", "published_at": "2016-07-24T02:30:21+00:00" }, { "id": "01a0bddb-51bb-7121-ac62-3369986c457d", "title": "Human genetic support for GLP1R agonism in diabetes…and heart disease?", "url": "https://plengegen.com/blog/glp1r/", "published_at": "2016-06-03T22:51:59+00:00" }, { "id": "01a0bddb-51bb-7121-ac62-3369995141df", "title": "Perspective on non-human animal models in drug R&D", "url": "https://plengegen.com/blog/animal-models/", "published_at": "2016-04-24T13:12:24+00:00" }, { "id": "01a0bddb-51bb-7121-ac62-3369996211a4", "title": "The path of most resistance – causal human biology and the druggable genome", "url": "https://plengegen.com/blog/path-resistance/", "published_at": "2016-04-16T21:58:06+00:00" }, { "id": "01a0bddb-51bb-7121-ac62-33699a1c3168", "title": "Learning to fly in drug discovery", "url": "https://plengegen.com/blog/learning-fly-drug-rd/", "published_at": "2016-03-03T18:54:53+00:00" }, { "id": "01a0bddb-51bb-7121-ac62-33699a2d2b55", "title": "Autoantibodies as experiments of nature for drug discovery | example in NEJM on thrombotic thrombocytopenic purpura (TTP)", "url": "https://plengegen.com/blog/autoantibodies-drug-discovery/", "published_at": "2016-02-14T17:36:54+00:00" }, { "id": "01a0bdde-2aad-72df-95a7-b4ddbafca6f9", "title": "Forget Neandertals – this Science study is about genotype-phenotype correlations in electronic health records (EHRs).", "url": "https://plengegen.com/blog/forget-neandertals/", "published_at": "2016-02-13T17:00:55+00:00" }, { "id": "01a0bdde-2aad-72df-95a7-b4ddbb4c0467", "title": "Design principles for complex systems: Legos for kids and the business world", "url": "https://plengegen.com/blog/design-principles-complex-systems/", "published_at": "2015-12-08T10:24:42+00:00" }, { "id": "01a0bdde-2aad-72df-95a7-b4ddbb9f33d5", "title": "Does innovation happen in large pharmaceutical companies? (spoiler alert: yes)", "url": "https://plengegen.com/blog/innovation-happen-large-pharmaceutical-companies-spoiler-alert-yes/", "published_at": "2015-10-09T11:29:46+00:00" }, { "id": "01a0bdde-2aad-72df-95a7-b4ddbc12e059", "title": "Article of the week: ARID5B–FTO–IRX3/IRX5 regulatory axis for drug discovery in obesity (NEJM)", "url": "https://plengegen.com/blog/arid5b-fto-irx3irx5-regulatory-axis-drug-discovery-obesity-nejm/", "published_at": "2015-08-21T13:53:42+00:00" }, { "id": "01a0bdde-2aad-72df-95a7-b4ddbcd56610", "title": "What innovations will revolutionize drug discovery? My three predictions.", "url": "https://plengegen.com/blog/innovations-revolutionize-drug-discovery-predictions/", "published_at": "2015-07-11T19:28:55+00:00" }, { "id": "01a0bdde-2aad-72df-95a7-b4ddbd528315", "title": "Mendelian randomization for drug discovery and development: highlights from Bristol meeting (June 2015)", "url": "https://plengegen.com/blog/mendelian-randomization-drug-discovery-development-highlights-bristol-meeting-june-2015/", "published_at": "2015-06-26T07:59:15+00:00" }, { "id": "01a0bdde-2aad-72df-95a7-b4ddbd7af848", "title": "Genetic & Pharmacogenomic (GpGx) retreat: integrate and elevate", "url": "https://plengegen.com/blog/genetic-pharmacogenomic-gpgx-retreat-integrate-elevate/", "published_at": "2015-06-17T18:31:05+00:00" }, { "id": "01a0bdde-2aad-72df-95a7-b4ddbe1fa8f0", "title": "Articles of the week: biomarkers for Alzheimer’s in JAMA.", "url": "https://plengegen.com/blog/articles-week-biomarkers-alzheimers-jama/", "published_at": "2015-05-26T12:37:20+00:00" }, { "id": "01a0bdde-2aad-72df-95a7-b4ddbe68f901", "title": "Recruiting clinical scientists into Translational Medicine", "url": "https://plengegen.com/blog/recruiting-physician-scientists-translational-medicine/", "published_at": "2015-05-18T19:25:09+00:00" }, { "id": "01a0bdde-2aad-72df-95a7-b4ddbeadb1e0", "title": "For those geneticists / genomicists who don’t know, immuno-oncology is really cool", "url": "https://plengegen.com/blog/geneticists-genomicists-dont-know-immuno-oncology-cool/", "published_at": "2015-04-16T09:58:24+00:00" }, { "id": "01a0bde0-c93a-702d-92f8-b097803c7c6a", "title": "Article of the week: allelic series model for drug discovery (TYK2 and autoimmunity)", "url": "https://plengegen.com/blog/article-week-allelic-series-model-drug-discovery-tyk2-autoimmunity/", "published_at": "2015-04-15T09:47:15+00:00" }, { "id": "01a0bde0-c93a-702d-92f8-b09780dccd27", "title": "Human genetics in Iceland – a glimpse into the future of genetic-based drug discovery", "url": "https://plengegen.com/blog/human-genetic-studies-iceland-glimpse-future-genetic-based-drug-discovery/", "published_at": "2015-03-29T22:16:44+00:00" }, { "id": "01a0bde0-c93a-702d-92f8-b09781792923", "title": "Articles of the week: IL23 and psoriasis, Mendelian randomization and IL1", "url": "https://plengegen.com/blog/articles-week-il23-psoriasis-mendelian-randomization-il1/", "published_at": "2015-03-09T18:56:02+00:00" }, { "id": "01a0bde0-c93a-702d-92f8-b09781f8c3c4", "title": "Articles of the week: experiments of nature in drug discovery", "url": "https://plengegen.com/blog/articles-week-experiments-nature-drug-discovery/", "published_at": "2015-02-20T07:54:49+00:00" }, { "id": "01a0bde0-c93a-702d-92f8-b097828cafc3", "title": "Articles of the week: human genetics to assess on-target adverse drug events", "url": "https://plengegen.com/blog/articles-week-human-genetics-assess-on-target-adverse-drug-events/", "published_at": "2015-02-07T21:02:34+00:00" }, { "id": "01a0bde0-c93a-702d-92f8-b09782939aaf", "title": "Articles of the week: Genetic forecasting – cell biology experimentally validates functional mutations from genome sequencing", "url": "https://plengegen.com/blog/genetic-forecasting-cell-biology-experimentally-validates-functional-mutations-complex-disease-sequencing-studies/", "published_at": "2015-02-04T02:02:51+00:00" }, { "id": "01a0bde0-c93a-702d-92f8-b0978320e32e", "title": "A letter to President Obama about precision medicine", "url": "https://plengegen.com/blog/letter-president-obama-precision-medicine/", "published_at": "2015-01-25T15:33:56+00:00" }, { "id": "01a0bde0-c93a-702d-92f8-b09783a3f65b", "title": "To graduate students in genetics: consider industry", "url": "https://plengegen.com/blog/graduate-students-genetics-industry/", "published_at": "2015-01-19T11:47:44+00:00" }, { "id": "01a0bde0-c93a-702d-92f8-b09784349f9a", "title": "Article of the week in genetics/genomics for drug discovery: from mutated genes to pathway screens", "url": "https://plengegen.com/blog/article-week-geneticsgenomics-drug-discovery-genes-screens/", "published_at": "2015-01-16T10:51:03+00:00" }, { "id": "01a0bde0-c93a-702d-92f8-b09784e182fc", "title": "Drones and drug discovery", "url": "https://plengegen.com/blog/drones-drug-discovery/", "published_at": "2015-01-04T04:32:10+00:00" }, { "id": "01a0bde3-40c8-7041-850b-e73a3d5cdfd3", "title": "Article of the week for genetics/genomics in drug discovery: Rise of the dead Cas9 (dCas9)", "url": "https://plengegen.com/blog/article-week-geneticsgenomics-drug-discovery-rise-dead-cas9-dcas9/", "published_at": "2014-12-19T12:36:43+00:00" }, { "id": "01a0bde3-40c8-7041-850b-e73a3d816b7e", "title": "Article of the week in genetics/genomics for drug discovery: Factor XI deficiency and venous thromboembolism", "url": "https://plengegen.com/blog/article-week-geneticsgenomics-drug-discovery-factor-xi-deficiency-venous-thromboembolism/", "published_at": "2014-12-11T12:35:55+00:00" }, { "id": "01a0bde3-40c8-7041-850b-e73a3e60d18e", "title": "Article of the week in genetics/genomics for drug discovery: APOC3 as therapeutic target", "url": "https://plengegen.com/blog/article-week-geneticsgenomics-drug-discovery-apoc3-therapeutic-target/", "published_at": "2014-12-05T13:24:29+00:00" }, { "id": "01a0bde3-40c8-7041-850b-e73a3ec99817", "title": "Personalized medicine for complex traits has different time horizons and scope of impact based on two categories: “genetic targets” and “large-effect variants”", "url": "https://plengegen.com/blog/personalized-medicine-time-horizons-scope-impact-based-categories-genetic-targets-large-effect-variants/", "published_at": "2014-11-15T16:17:58+00:00" }, { "id": "01a0bde3-40c8-7041-850b-e73a3f48d14e", "title": "How many genomes is enough?", "url": "https://plengegen.com/blog/genomes-enough/", "published_at": "2014-11-12T22:26:24+00:00" }, { "id": "01a0bde3-40c8-7041-850b-e73a3f850b19", "title": "Decision-making Part 2: genetics and assays for drug discovery", "url": "https://plengegen.com/blog/decision-making-part-2-genetics-assays-drug-discovery/", "published_at": "2014-09-08T11:37:41+00:00" }, { "id": "01a0bde3-40c8-7041-850b-e73a3feb6bd2", "title": "Genetics and decision-making in drug discovery Part 1: overview", "url": "https://plengegen.com/blog/genetics-decision-making-drug-discovery-part-1-overview/", "published_at": "2014-08-29T08:47:47+00:00" }, { "id": "01a0bde3-40c8-7041-850b-e73a3ff3c1fb", "title": "Part 4: genes to pathways to drug targets", "url": "https://plengegen.com/blog/part-4-genes-pathways-drug-targets/", "published_at": "2014-08-20T09:54:20+00:00" }, { "id": "01a0bde3-40c8-7041-850b-e73a40de1ba7", "title": "Combining the strengths of academia and industry – it’s in our genes!", "url": "https://plengegen.com/blog/combining-strengths-academia-industry-its-genes/", "published_at": "2014-08-18T12:02:03+00:00" }, { "id": "01a0bde3-40c8-7041-850b-e73a41dc8dca", "title": "Part 3: Single genes to drug targets", "url": "https://plengegen.com/blog/part-3-single-genes-drug-targets/", "published_at": "2014-08-16T20:58:26+00:00" }, { "id": "01a0bde5-b51f-719e-95ec-5dd8b6967474", "title": "Part 2 – Phenotype matters!", "url": "https://plengegen.com/blog/part-ii-phenotype-matters/", "published_at": "2014-08-08T23:12:53+00:00" }, { "id": "01a0bde5-b51f-719e-95ec-5dd8b77fbb88", "title": "Part 1: The case for genetics in drug discovery", "url": "https://plengegen.com/blog/part-1-case-genetics-drug-discovery/", "published_at": "2014-08-02T12:14:16+00:00" }, { "id": "01a0bde5-b51f-719e-95ec-5dd8b875b26b", "title": "Why I tweet about drug discovery (hint: it is about humans)", "url": "https://plengegen.com/blog/tweet-drug-discovery-hint-humans/", "published_at": "2014-07-26T19:31:45+00:00" }, { "id": "01a0bde5-b51f-719e-95ec-5dd8b94b9cf2", "title": "Pendulum swings blindly in the genetic basis of complex traits.", "url": "https://plengegen.com/blog/pendulum-swings-blindly-genetic-basis-complex-traits/", "published_at": "2013-06-18T14:51:32+00:00" }, { "id": "01a0bde5-b51f-719e-95ec-5dd8ba014548", "title": "Academics AND industry – a personal perspective on human genetics for drug discovery", "url": "https://plengegen.com/blog/academics-industry-personal-perspective-human-genetics-drug-discovery/", "published_at": "2013-06-04T13:30:47+00:00" }, { "id": "01a0bde5-b51f-719e-95ec-5dd8bafe5dee", "title": "Keltner List for genetics and drug discovery", "url": "https://plengegen.com/blog/keltner-list-genetics-drug-discovery/", "published_at": "2013-05-17T00:44:24+00:00" }, { "id": "01a0bde5-b51f-719e-95ec-5dd8bb692bfc", "title": "The databases we need", "url": "https://plengegen.com/blog/databases/", "published_at": "2013-05-04T12:41:27+00:00" }, { "id": "01a0bde5-b51f-719e-95ec-5dd8bbd7660d", "title": "Disease deconstruction through drug exposure", "url": "https://plengegen.com/blog/disease-deconstruction-drug-exposure/", "published_at": "2013-04-25T11:44:15+00:00" }, { "id": "01a0bde5-b51f-719e-95ec-5dd8bc7e7e16", "title": "Clinical features of rheumatoid arthritis", "url": "https://plengegen.com/blog/clinical-features-rheumatoid-arthritis/", "published_at": "2013-04-14T16:01:42+00:00" }, { "id": "01a0bde5-b51f-719e-95ec-5dd8bcbe7cbd", "title": "Systems immunology – human genetics to derive biological insight into the human immune system", "url": "https://plengegen.com/blog/systems-immunology-human-genetics-derive-biological-insight-human-immune-system/", "published_at": "2013-04-03T01:27:02+00:00" }, { "id": "01a0bde8-2bf8-720e-97da-d386389b5e0c", "title": "Mendelian randomization – differentiating between cause and consequence", "url": "https://plengegen.com/blog/mendelian-randomization-differentiating-consequence/", "published_at": "2013-03-31T14:00:15+00:00" }, { "id": "01a0bde8-2bf8-720e-97da-d38638cae1c5", "title": "Personalized medicine vs precision medicine", "url": "https://plengegen.com/blog/personalized-medicine-precision-medicine/", "published_at": "2013-03-16T12:13:10+00:00" }, { "id": "01a0bde8-2bf8-720e-97da-d38638e62b6c", "title": "Polygenic predictors of complex traits", "url": "https://plengegen.com/blog/polygenic-predictors-complex-traits/", "published_at": "2013-03-13T15:50:40+00:00" }, { "id": "01a0bde8-2bf8-720e-97da-d38639189b54", "title": "Pharmaco-convergence", "url": "https://plengegen.com/blog/pharmaco-convergence/", "published_at": "2013-02-08T20:14:21+00:00" }, { "id": "01a0bde8-2bf8-720e-97da-d386396b56f9", "title": "Genetic exceptionalism", "url": "https://plengegen.com/blog/genetic-exceptionalism/", "published_at": "2013-02-01T20:37:55+00:00" } ] posts Claim your blog
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plengegen.com

2026

Reclaiming the missing positiveoriginal ↗
30 Jun 2026
The Jagged Line: Why the Best Careers Never Run Straightoriginal ↗
26 Jun 2026
Connected by Design: How AI and Automation are Transforming Drug Discovery at BMSoriginal ↗
5 May 2026
Breaking from the Herd: How Biopharma Can Escape Moloch’s Traporiginal ↗
10 Apr 2026
The race between the bull and the bear: U.S. biopharma outlook in 2026original ↗
29 Jan 2026
From Sapling to Forest: Blended Innovation and the Future of Drug Discoveryoriginal ↗
8 Jan 2026

2025

Smart Bets, Bold Science: Building Winning Hands in Drug Discoveryoriginal ↗
27 Oct 2025
Optimizing value creation in biopharma is like “the flop” in Texas hold ‘emoriginal ↗
27 Mar 2025
AI Unleashed: Transforming Drug Discovery from Theory to Practiceoriginal ↗
7 Jan 2025

2024

Advice to my younger selforiginal ↗
27 Sept 2024
Sequential immunotherapy for functional cures in autoimmunityoriginal ↗
5 Jun 2024

2023

Increasing R&D productivity: “Bullseye, Aim, Fire!”original ↗
27 Sept 2023
Discovery moments: TYK2 pseudokinase inhibitororiginal ↗
28 Jan 2023

2022

The AI Challenge in drug discovery and development: What is “truth”? original ↗
7 Jan 2022

2021

Is drug R&D more like poker or chess?original ↗
15 Nov 2021
Programmable therapeutics – more than pure imaginationoriginal ↗
28 May 2021
Guest blog: Lessons Learned from Misadventure – Kristen Hegeoriginal ↗
10 Mar 2021

2020

Creating a “virtual bubble” for safe return in K-12 schoolsoriginal ↗
9 Sept 2020
Drug repurposing in SARS-CoV-2 / COVID-19: preventing the maladaptive immune response leading to critical disease requiring ICU care.original ↗
8 Apr 2020
The clickable genome: click on any gene and generate a function-phenotype map (i.e., genetic dose-response curve)original ↗
12 Jan 2020

2019

Mechanism, magnitude, and markers, oh my!original ↗
28 Sept 2019
Adverse drug event (ADE) phenome-wide association study (PheWAS) with ACLY geneoriginal ↗
26 Mar 2019
Tipping point for digital health in drug discovery and developmentoriginal ↗
6 Jan 2019

2018

How to build a genetic dose-response portal in 7 yearsoriginal ↗
9 Dec 2018
Pharmacogenetics by design (not by accident)original ↗
21 Oct 2018
A tale of tails: polygenic risk scores and healthcare reimaginedoriginal ↗
28 Aug 2018
Protein quantitative trait loci (pQTLs): an emerging resource for genetic-driven drug discoveryoriginal ↗
7 Jun 2018
Matching therapeutic modality and molecular mechanismoriginal ↗
1 May 2018
NASH, HSD17B13 and era of programmable therapeuticsoriginal ↗
13 Apr 2018

2017

Genetically driven tissue-specific pathogenicityoriginal ↗
28 Dec 2017
PheWAS and FinnGenoriginal ↗
19 Dec 2017
Celebrating new therapeutic modalitiesoriginal ↗
27 Sept 2017
Omnigenic drug discoveryoriginal ↗
19 Jun 2017
Human genetics to predict therapeutic window: case study with BAFF and belimumaboriginal ↗
30 Apr 2017
Call for a Human Knockout Project for drug discovery & developmentoriginal ↗
23 Apr 2017
Odds & ends: this week’s examples of a discipline approach to R&Doriginal ↗
31 Mar 2017
Make no mistake: PCSK9 and the FOURIER clinical outcome study represent a triumph for genetic-driven drug discoveryoriginal ↗
24 Mar 2017
Article of the week: substrate reduction therapy for Parkinson’s disease guided by a biochemical understanding of GBA mutationsoriginal ↗
15 Mar 2017
The inconvenient path of precision medicine in drug developmentoriginal ↗
9 Mar 2017
Towards programmable therapeuticsoriginal ↗
2 Mar 2017

2016

Polygenic models for drug discovery | ultra-rare variants in schizophreniaoriginal ↗
5 Oct 2016
Short blog on academic-industry partnershipsoriginal ↗
15 Sept 2016
Beware of the personal narrative: failure is inherent to successoriginal ↗
12 Aug 2016
Commentary on my STM Perspective, “Disciplined approach to drug discovery and early development”original ↗
28 Jul 2016
Commentary on Discussion Paper by Munos and Orloff, “Disruptive Innovation and Transformation of the Drug Discovery and Development Enterprise”original ↗
24 Jul 2016
Human genetic support for GLP1R agonism in diabetes…and heart disease?original ↗
3 Jun 2016
Perspective on non-human animal models in drug R&Doriginal ↗
24 Apr 2016
The path of most resistance – causal human biology and the druggable genomeoriginal ↗
16 Apr 2016
Learning to fly in drug discoveryoriginal ↗
3 Mar 2016
Autoantibodies as experiments of nature for drug discovery | example in NEJM on thrombotic thrombocytopenic purpura (TTP)original ↗
14 Feb 2016
Forget Neandertals – this Science study is about genotype-phenotype correlations in electronic health records (EHRs).original ↗
13 Feb 2016

2015

Design principles for complex systems: Legos for kids and the business worldoriginal ↗
8 Dec 2015
Does innovation happen in large pharmaceutical companies? (spoiler alert: yes)original ↗
9 Oct 2015
Article of the week: ARID5B–FTO–IRX3/IRX5 regulatory axis for drug discovery in obesity (NEJM)original ↗
21 Aug 2015
What innovations will revolutionize drug discovery? My three predictions.original ↗
11 Jul 2015
Mendelian randomization for drug discovery and development: highlights from Bristol meeting (June 2015)original ↗
26 Jun 2015
Genetic & Pharmacogenomic (GpGx) retreat: integrate and elevateoriginal ↗
17 Jun 2015
Articles of the week: biomarkers for Alzheimer’s in JAMA.original ↗
26 May 2015
Recruiting clinical scientists into Translational Medicineoriginal ↗
18 May 2015
For those geneticists / genomicists who don’t know, immuno-oncology is really cooloriginal ↗
16 Apr 2015
Article of the week: allelic series model for drug discovery (TYK2 and autoimmunity)original ↗
15 Apr 2015
Human genetics in Iceland – a glimpse into the future of genetic-based drug discoveryoriginal ↗
29 Mar 2015
Articles of the week: IL23 and psoriasis, Mendelian randomization and IL1original ↗
9 Mar 2015
Articles of the week: experiments of nature in drug discoveryoriginal ↗
20 Feb 2015
Articles of the week: human genetics to assess on-target adverse drug eventsoriginal ↗
7 Feb 2015
Articles of the week: Genetic forecasting – cell biology experimentally validates functional mutations from genome sequencingoriginal ↗
4 Feb 2015
A letter to President Obama about precision medicineoriginal ↗
25 Jan 2015
To graduate students in genetics: consider industryoriginal ↗
19 Jan 2015
Article of the week in genetics/genomics for drug discovery: from mutated genes to pathway screensoriginal ↗
16 Jan 2015
Drones and drug discoveryoriginal ↗
4 Jan 2015

2014

Article of the week for genetics/genomics in drug discovery: Rise of the dead Cas9 (dCas9)original ↗
19 Dec 2014
Article of the week in genetics/genomics for drug discovery: Factor XI deficiency and venous thromboembolismoriginal ↗
11 Dec 2014
Article of the week in genetics/genomics for drug discovery: APOC3 as therapeutic targetoriginal ↗
5 Dec 2014
Personalized medicine for complex traits has different time horizons and scope of impact based on two categories: “genetic targets” and “large-effect variants”original ↗
15 Nov 2014
How many genomes is enough?original ↗
12 Nov 2014
Decision-making Part 2: genetics and assays for drug discoveryoriginal ↗
8 Sept 2014
Genetics and decision-making in drug discovery Part 1: overvieworiginal ↗
29 Aug 2014
Part 4: genes to pathways to drug targetsoriginal ↗
20 Aug 2014
Combining the strengths of academia and industry – it’s in our genes!original ↗
18 Aug 2014
Part 3: Single genes to drug targetsoriginal ↗
16 Aug 2014
Part 2 – Phenotype matters!original ↗
8 Aug 2014
Part 1: The case for genetics in drug discoveryoriginal ↗
2 Aug 2014
Why I tweet about drug discovery (hint: it is about humans)original ↗
26 Jul 2014

2013

Pendulum swings blindly in the genetic basis of complex traits.original ↗
18 Jun 2013
Academics AND industry – a personal perspective on human genetics for drug discoveryoriginal ↗
4 Jun 2013
Keltner List for genetics and drug discoveryoriginal ↗
17 May 2013
The databases we needoriginal ↗
4 May 2013
Disease deconstruction through drug exposureoriginal ↗
25 Apr 2013
Clinical features of rheumatoid arthritisoriginal ↗
14 Apr 2013
Systems immunology – human genetics to derive biological insight into the human immune systemoriginal ↗
3 Apr 2013
Mendelian randomization – differentiating between cause and consequenceoriginal ↗
31 Mar 2013
Personalized medicine vs precision medicineoriginal ↗
16 Mar 2013
Polygenic predictors of complex traitsoriginal ↗
13 Mar 2013
Pharmaco-convergenceoriginal ↗
8 Feb 2013
Genetic exceptionalismoriginal ↗
1 Feb 2013